表观遗传时钟加速与美国成年人营养不良之间的关联:一个横截面研究
An Zhou1, Qun Ye1,2, Yonghui Wei1
1Department of Genetics, College of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
JPEN. Journal of parenteral and enteral nutrition
|May 27, 2025
概括
营养不良显著加速生物衰老,正如GrimAge2Mort和DunedinPoAm.Am等表观遗传钟所示. 这凸显了营养状况对衰老过程的影响.
科学领域:
- 老年学是一门学科.
- 营养科学 营养科学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 研究了营养评估工具 (CONUT,GNRI,NPS) 和表观遗传钟之间的联系.
- 评估了营养不良对生物衰老的影响.
研究的目的:
- 评估营养状况与表观遗传衰老加速之间的关系.
- 为了确定与营养相关的衰老的可靠表观遗传标记.
主要方法:
- 利用来自NHANES数据库 (1999-2002) 的2532名参与者 (≥50岁) 的数据.
- 使用CONUT,GNRI和NPS评估参与者,对12个表观遗传钟进行分析.
- 采用多重线性回归模型,经过调整以考虑混因素.
主要成果:
- 营养不良的发病率:13.5% (CONUT),4.2% (GNRI),46.8% (NPS) 在美国.
- 中度至严重的营养不良与显著的表观遗传年龄加速相关 (例如,GrimAge2Mort高达4.19年).
- 在营养不良的严重程度和表观遗传加快年龄之间观察到剂量反应关系.
结论:
- 首次有系统的证据将营养不良与生物衰老的大幅加速联系起来.
- GrimAge2Mort,DunedinPoAm和YangCell是与营养相关的生物衰老的有希望的指标.
- 研究结果提供了对营养不良对衰老的影响的见解,并为临床营养策略提供了信息.
关键词:
尼汉斯 (NHANES) 是一个名人.生物衰老 生物衰老遗传表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表营养不良 营养不良 营养不良相关概念视频
Epigenetic Regulation
3.7K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.7K
Epigenetic Regulation
33.5K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.5K
Metabolic States of the Body: Fasting and Starvation
2.7K
During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
2.7K
Nature and Nurture
22.2K
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
22.2K
Obesity
1.1K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.1K


