铁代谢标记物与粘性菌根症的关联:一个病例对照研究
Ankita Semwal1, Amit Kumar Tyagi1, Prasan Kumar Panda2
1Department of Otorhinolaryngology & Head-Neck Surgery, All India Institute of Medical Sciences, Rishikesh, 249203 Uttarakhand India.
概括
血清费里丁水平升高与粘膜性菌根症的严重程度有关. 较高的费里丁含量表明严重结局的风险更高,特别是在患有糖尿病等危险因素的患者中.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 铁的新陈代谢 铁的新陈代谢
背景情况:
- 粘菌菌是一种严重的真菌感染,经常影响免疫力低下的个体.
- 铁代谢失调与粘膜菌病的发生有关.
- 血清费里丁是铁储存的标志物,需要在粘性菌根症中进行调查.
研究的目的:
- 为了确定粘膜菌和铁代谢标志物之间的关联.
- 为了将血清费里丁水平与粘膜菌病的临床阶段和严重程度相关联.
主要方法:
- 一个病例对照研究,涉及50名活检证明的粘性菌根病患者和50名匹配的对照.
- 对照组根据年龄,性别和已知的粘膜菌病风险因素进行了匹配.
- 测量和比较了血清铁,转激素和和血清费里水平.
主要成果:
- 与对照组相比,菌菌病患者的血清铁和转林和水平显著降低.
- 平均血清费里水平在粘性肌病病例 (2087.6 ng/ml) 和对照 (174.5 ng/ml) 中显著更高.
- Rhino-orbital mucormycosis是最常见的表现 (50%),糖尿病是普遍存在的危险因素 (96%).
结论:
- 血清费里水平升高似乎是粘性菌症严重程度的重要指标.
- 血清费里丁水平较高的患者需要密切监测,以避免潜在的严重后果.
- 管理策略应考虑菌素升高和菌菌病患者的并发风险因素.
更多相关视频
07:58Use of Image Cytometry for Quantification of Pathogenic Fungi in Association with Host Cells
Published on: June 19, 2013
13.1K
04:48Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry CE-ICP-MS for Quantification of Iron Redox Species FeII, FeIII
Published on: May 4, 2020
8.2K
相关概念视频
Fungal Group Zygomycota
138
Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
138
Fungal Phylum Microsporidia
128
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
128
