与COVID相关的一种罕见的深部感染:病因 - 细胞巨病毒
Şeyda Akbal Çufalı1, Kürşat Murat Özcan2, Ayşe Seçil Kayalı Dinç2
1Department of Otolaryngology-Head and Neck Surgery, Sağlık Bilimleri Üniversitesi, Ankara City Hospital, Universiteler Mahallesi 1604. Cadde No: 9, Çankaya/Ankara, Turkey.
细胞巨乳病毒 (CMV) 可以导致抗标准治疗的深感染,特别是在糖尿病和COVID-19病史的老年患者中. 通过组织采样和抗病毒疗法进行早期诊断对于有效的管理至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 病毒学 病毒学
背景情况:
- 深部感染是严重的,可能危及生命的疾病,起源于口腔或口腔大.
- 标准治疗通常针对细菌和真菌病原体.
- 患有糖尿病等并发症的老年患者和以前的COVID-19感染可能会带来独特的挑战.
研究的目的:
- 突出细胞巨乳病毒 (CMV) 作为治疗耐药性深部感染的潜在原因.
- 强调在耐火病例中考虑罕见病原体的重要性.
- 展示组织采样和分子方法的诊断实用性.
主要方法:
- 关于两名患有深感染的老年患者的病例报告.
- 对抗生素和抗真菌药物的治疗反应的评估.
- 使用组织样本和分子检测 (CMV DNA PCR) 确认细胞巨乳病毒 (CMV) 的诊断.
- 评估抗病毒治疗后的临床改善情况.
主要成果:
- 两位患者都出现了深部感染,对传统的抗生素和抗真菌治疗没有反应.
- 最初的CMV血液检测结果为阴性,但组织样本证实了CMV阳性.
- 开始抗病毒疗法导致了两种病例的显著临床改善.
结论:
- 在深部感染的差异诊断中,应考虑细胞巨乳病毒 (CMV),特别是在免疫功能低下的患者或有CMV暴露史的患者中.
- 组织采样和分子诊断对于识别不常见的病原体,如CMV至关重要,当常规测试给出负结果时.
- 抗病毒疗法可以有效地管理CMV诱导的深部感染.
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