多中心SPAN试验法苏迪尔在缺血性中风中的试验
Takahiko Imai1, Andreia Lopes de Morais1, Xuyan Jin1
1Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston, MA (T.I., A.L.d.M., X.J., T.Q., J.B.M., C.A.).
Stroke
|May 27, 2025
概括
作为rho相关激酶抑制剂的法苏迪尔 (Fasudil) 在动物模型中改善了缺血性中风的结果,特别是在老年小鼠中. 这表明未来中风治疗的潜力.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 脑卒中研究 脑卒中研究
背景情况:
- 脑卒中临床前评估网络 (SPAN) 是一个多中心试验网络,评估实验性急性脑卒中中的脑保护性干预措施.
- 这项研究报告了在SPAN试验中使用过渡焦点缺血性中风的动物模型中使用的Rho相关激酶抑制剂fasudil.
研究的目的:
- 评估法苏迪尔在缺血性中风的临床前动物模型中对初级和二级结果的疗效.
- 在各种临床前模型中评估法苏迪尔的治疗潜力,包括老化和肥胖的小鼠和自发高血压的老鼠.
主要方法:
- 费苏迪尔 (10 mg/kg) 每12小时进行一次腹膜内注射,每次6次,在60分钟的中脑动脉封闭模型中,从再输血开始.
- 这项研究在各种动物模型中比较了法苏迪尔治疗臂 (n=345) 与组合的车辆控制臂 (n=344).
- 主要终点是28日修改的角测试性能,使用修改的治疗意图队列进行分析.
主要成果:
- 费苏迪尔显著改善了小鼠的主要结局 (PI估计,0.57;P=0.022).
- 法苏迪尔的有益作用在老年小鼠中更为明显,并且当缺血发生在活跃的昼夜阶段时.
- 在自发高血压的老鼠中没有观察到法苏迪尔的显著益处.
结论:
- 法苏迪尔在动物模型中表现出有利的治疗特征,用于缺血性中风.
- 这些发现支持进一步转化开发用于治疗缺血性中风的罗相关激酶抑制剂.
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