不同类型药物的对CRSwNP嗅觉功能障碍的影响:系统性审查和网络元分析
Lei Zhou1, Yijie Fu2, Jing Zhang1
1School of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
The Laryngoscope
|May 27, 2025
概括
生物药物,特别是dupilumab,显著改善了慢性鼻炎与鼻息肉 (CRSwNP) 的患者的嗅觉功能障碍. 这一元分析强调了它们在主观和客观嗅觉改善方面比安慰剂更有效.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 嗅觉功能障碍是慢性鼻炎与鼻 (CRSwNP) 的常见并发症.
- 药理疗法旨在改善受影响患者的嗅觉.
- 评估治疗疗效对于临床决策至关重要.
研究的目的:
- 进行网络元分析,评估CRSwNP患者嗅觉障碍的各种药理疗法的疗效.
- 为了比较不同药物治疗对嗅觉功能的主观和客观指标的影响.
主要方法:
- 在PubMed,Embase,Cochrane图书馆和Web of Science进行全面的文献搜索,截至2024年8月.
- 包括19个随机对照试验 (RCT),涉及2354名参与者.
- 使用Stata 14.2进行的网络元分析,以合成治疗效应.
主要成果:
- 与安慰剂相比,生物体在主观嗅觉功能障碍中表现出最显著的改善 (SMD = -0.75).
- 生物药物在改善客观嗅觉功能方面也显示出最大的影响 (SMD = 0.93).
- 杜皮卢马布被确定为对主观 (SMD = -1.30) 和客观 (MD = 11.13) 嗅觉功能障碍最有效的生物药物.
结论:
- 生物药物,特别是dupilumab,在改善CRSwNP患者的嗅觉感觉方面显示出有希望的疗效.
- 限制包括需要标准化嗅觉评估方法和更大规模的RCT.
- 建议进行进一步的研究,以指导临床医生和患者的最佳治疗选择.
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