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探索肠-大脑轴的因果关系:孟德尔对肠道微生物群,代谢物和认知的随机化研究

Sunan Gao^1,2, Angela Y Xiao³, Siyu Zou^2,4

¹School of Statistics, Renmin University of China, Beijing, China.

Food & function

|May 27, 2025

概括

这项研究揭示了肠道细菌,代谢物和认知功能之间的因果关系,支持肠-大脑轴. 研究结果表明,潜在的功能性食物和个性化的营养策略可以提高认知健康.

科学领域:

肠-大脑轴研究研究
代谢学和微生物学
营养神经科学营养神经科学

背景情况:

肠道微生物群,代谢物和认知功能之间的关系尚未完全理解.
研究这些联系对于理解肠-大脑轴和制定有针对性的健康干预措施至关重要.
功能性食品和个性化营养对认知健康有前途,但需要基于证据的目标.

研究的目的:

研究肠道微生物群和认知表型之间的代谢物因果调解效应.
探索这些途径对功能性食品发展的影响.
在认知健康中提供支持肠-大脑轴机制的证据.

主要方法:

使用了系统的门德尔随机化 (MR) 分析.
我们利用了肠道微生物种群,血清代谢物和认知表型的全基因组关联研究数据.
进行了反变量加权估计,MR敏感性分析,代谢途径分析和两步MR.

主要成果:

在微生物群或代谢物和认知表型 (FDR < 0.05) 之间确定了七种因果关系.
增加*Clostridiales id.1863*和1-linoleoylglycerophosphoethanolamine的丰度与更好的认知特征有关.
确定了两条重要的调解途径,其中同胺调解了Turicibacter对情绪识别的影响.

结论:

这项研究提供了肠道微生物群,血清代谢物和认知功能之间的因果关系的证据,支持肠-大脑轴.
丰富的代谢途径,包括α-烯酸和酸代谢,突出显示了omega-3和omega-6脂肪酸的作用.
研究结果表明,功能性食品开发和个性化营养的潜在目标是改善认知健康.

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