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Updated: Mar 1, 2026

Brain Slice Biotinylation: An Ex Vivo Approach to Measure Region-specific Plasma Membrane Protein Trafficking in Adult Neurons
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作为离子通道贩运的新型调节剂,DENND3的分子和功能表征

Shan Gao1, Dan Ye1, Raquel Neves1

  • 1Windland Smith Rice Sudden Death Genomics Laboratory, Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota.

Heart rhythm
|May 27, 2025
PubMed
概括

一种罕见的DENND3基因变异 (p.R534S) 破坏Rab GTPase通路,改变心脏离子通道功能并增加心律失常风险. 这一发现将DENND3和Rab GTPases与致死性心律失常综合征联系起来.

关键词:
节律失常 (arrhythmia) 是一种心律失常.遗传学 遗传学 是一个异常发病的心室动是异常发病的心室动离子通道的离子通道膜贩运活动 膜贩运

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