在OSCC进展中,牙斑块和唾液微生物群的动态变化
Man Zhang1,2, Hailin Zhang1, Ao Hong3
1The Affiliated Cancer Hospital of Xiangya School of Medicine, Hunan Cancer Hospital, Central South University, Changsha, Hunan, China.
Clinical oral investigations
|May 27, 2025
概括
口腔癌的进展会改变口腔微生物及其基因组. 差异化口腔状细胞癌 (OSCC) 显示病原体和毒性因子增加,这表明它在瘤发生中发挥了作用.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 在瘤学瘤学.
背景情况:
- 口腔状细胞癌 (OSCC) 是一个重要的全球健康问题.
- 人们越来越认识到口腔微生物组在OSCC发展和进展中的作用.
- 了解微生物转变和基因组改变对于有针对性的干预至关重要.
研究的目的:
- 研究在OSCC进展过程中唾液和牙斑中的微生物组成和基因组学变化的研究.
- 确定与OSCC瘤分化相关的特定毒性因素和途径.
- 探索微生物资料作为诊断或治疗点的潜力.
主要方法:
- 使用元基因组测序分析了来自OSCC患者的64个唾液和牙斑样本.
- 样本根据瘤分化阶段进行分类.
- 进行了基因组和功能通路分析,以确定关键的微生物元素.
主要成果:
- 在生态区域和差异化程度之间观察到微生物组成和基因组概况的显著差异.
- 在差异化不良的OSCC中,发现了 Porphyromonas gingivalis 和 Fusobacterium nucleatum 等特定病原体的丰度增加.
- 微生物多样性和稳定性与瘤T阶段相关,并且在晚期发现了增加的毒性因素.
结论:
- OSCC进展的特点是口腔微生物群落及其基因组潜力的明显变化.
- 在差差分化的OSCC中,特定病原体和毒性因子的水平升高表明它们参与了口腔癌的发病过程.
- 这些发现凸显了开发基于口腔微生物群的新型诊断生物标志物和治疗策略的潜力.
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