在患有自闭症谱系障碍的人群中患帕金森病的风险
Weiyao Yin1, Abraham Reichenberg2,3, Michal Schnaider Beeri4
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
JAMA neurology
|May 27, 2025
概括
患有自闭症谱系障碍 (ASD) 的人患帕金森病 (PD) 的风险明显更高. 这种关联表明,这些神经疾病之间存在潜在的共同生物基础.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 流行病学 流行病学
背景情况:
- 新兴研究表明自闭症谱系障碍 (ASD) 和帕金森病 (PD) 之间存在潜在的生物联系.
- 需要进行大规模的纵向研究,以确认ASD患者患PD的风险增加.
研究的目的:
- 调查ASD诊断与随后患PD的风险之间的关联.
- 探索这种关系中潜在的改变因素,如早产,抑郁症和药物使用.
主要方法:
- 一项全国性的基于人口的前性队列研究,利用瑞典国家登记册.
- 包括1974年至1999年间出生的个人,从20岁到2022年12月的随访.
- 普森回归分析用于量化ASD和无ASD个体的PD相对风险 (RR),调整共变量.
主要成果:
- 该研究包括超过220万个人,其中51,954人被诊断为ASD.
- 与没有ASD的人相比,患有ASD的人患PD的风险增加了4.43倍 (RR,4.43 [95% CI,2.92-6.72]).
- 抑郁症和抗抑郁药的使用独立地与PD风险增加有关,而抗精神病药物暴露显示风险降低.
结论:
- 自闭症谱系障碍与帕金森病的风险显著增加有关.
- 这些发现表明神经发育障碍和神经退行性疾病 (如PD) 之间存在潜在的共同潜在病因.
- 需要提高对ASD患者长期神经风险的临床意识.
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