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在恶性胰岛素瘤中进行受体放射性核素治疗

David A Pattison, Grace Kong, Timothy Akhurst

Endocrine-related cancer

|May 27, 2025

概括

受体放射性核素疗法 (PRRT) 通过在93%的患者中缓解低血糖症,有效地管理恶性胰岛素瘤 (MI). 虽然复发会发生,但PRRT重复治疗提供了持久的疾病控制,并具有可管理的副作用.

科学领域:

在瘤学瘤学.
核医学就是核医学.
内分泌学在内分泌学.

背景情况:

恶性胰岛素瘤 (MI) 提出了复杂的管理挑战,平衡低血糖控制与减少瘤负担.
用受体放射性核素疗法 (PRRT) 治疗的MI患者的长期结果需要进一步分析.

研究的目的:

为了评估[177Lu]Lu-DOTATATE (LuTATE) PRRT在患有恶性胰岛素瘤的患者的长期疗效和安全性.
评估PRRT对低血糖,瘤控制和心脏病发作中的存活率的影响.

主要方法:

在两个澳大利亚NET中心,在2004-2022年期间接受了LuTATE治疗的15名恶性胰岛素瘤患者的回顾性审查.
低血糖症解决/复发,成像/生化反应,副作用,无进展生存 (PFS) 和整体生存 (OS) 的评估.
分析包括PRRT周期,累积活性和同时进行放射敏感化疗.

主要成果:

在93%的患者中,PRRT实现了低血糖症的缓解,缓解时间中位数为23.8个月.
50%的受试者出现复发,特别是在高度瘤中,但在所有情况下,重复治疗都是成功的.
中位数PFS为17.9个月,中位数OS为50.1个月,可管理的毒性包括骨髓抑制和低血糖症爆发.

结论:

PRRT为恶性胰岛素瘤提供持久的低血糖和瘤疾病控制.
用PRRT重复治疗是有效的管理复发性低血糖症.
多学科护理对于管理治疗相关的毒性,如低血糖症爆发,至关重要.

关键词:

网络网络网络网络网络这是一个很大的问题.PRRT PRRT 低血糖症低血糖症恶性的胰岛素瘤神经内分泌瘤的神经内分泌瘤

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