局部C1q/TNF相关蛋白1通过调节巨细胞激活来减轻脏炎症和纤维化
Fei Wang1,2, Zhe Gong3, Nianjia Yang4
1Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, People's Republic of China.
American journal of physiology. Renal physiology
|May 27, 2025
概括
脏中C1q/TNF相关蛋白1 (CTRP1) 的升高调节通过抑制巨细胞激活来减少慢性病 (CKD) 纤维化和炎症. CTRP1是CKD的一个潜在的治疗点.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 慢性病 (CKD) 涉及持续的炎症和纤维化,由于不清楚的发病因而带来治疗挑战.
- 与C1q/TNF相关的蛋白1 (CTRP1) 与纤维化和其他组织的炎症有关,这表明它可能在CKD中发挥作用.
研究的目的:
- 调查CTRP1在患者和小鼠模型中CKD病变的作用.
- 探索CTRP1作为缓解脏炎症和纤维化的潜在治疗标.
主要方法:
- 从CKD患者的血和组织中评估CTRP1表达.
- 在CKD小鼠模型中利用腺相关CTRP1来上调脏CTRP1.
- 研究了CTRP1对巨细胞激活,炎症基因表达和纤维细胞激活 in vitro 和 in vivo 的影响.
主要成果:
- CTRP1表达在血中升高,但在CKD患者的脏组织中降低.
- 在小鼠中,中CTRP1表达的增加与纤维化,炎症和巨细胞积累/激活的减少相关.
- CTRP1抑制了转化生长因子β1 (TGFβ1) 诱导的巨细胞M2关联基因和YAP/TAZ.
- 在体外中,CTRP1部分降低了受脂聚糖 (LPS) 刺激的促炎性基因表达.
结论:
- 局部CTRP1通过调节巨细胞激活,作为慢性炎症和纤维化的调节剂.
- 增加脏CTRP1表达为CKD提供了一个新的治疗策略.
- 在CKD患者中,CTRP1可以作为预测标记物和/或治疗标.
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