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Updated: Sep 20, 2025

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YAP通过Rho GTPase开关控制细胞迁移和入侵

Sagar R Shah1,2, Chunxiao Ren3, Nathaniel D Tippens2

  • 1Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

Science signaling
|May 27, 2025
PubMed
概括

转录协活性剂YAP通过激活TRIO促进细胞迁移,从而导致Rac1激活和RhoA抑制. 这种YAP-TRIO-Rho信号通路对于细胞入侵至关重要,特别是在质母细胞瘤中.

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