基于智能手机和平板电脑的工具来评估临床前阿尔茨海默病和轻度认知障碍患者的认知能力:范围审查
Rosanne L van den Berg1,2,3, Sophie M van der Landen1,2, Matthijs J Keijzer1,2,4
1Alzheimer Center Amsterdam, Neurology, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Journal of medical Internet research
|May 27, 2025
概括
早期阿尔茨海默病 (AD) 检测的数字工具显示出希望,但对其心理特性的严格验证往往缺乏. 需要进一步的研究来确保这些认知评估技术在临床上对广泛实施有用.
科学领域:
- 数字卫生技术数字卫生技术
- 评估神经退行性疾病的评估
- 认知生物标志物 认知生物标志物
背景情况:
- 在阿尔茨海默病 (AD) 中早期发现认知衰退至关重要,但具有挑战性.
- 数字工具为识别临床前阿尔茨海默病和轻度认知障碍 (MCI) 中微妙的认知变化提供了潜力.
- 目前还没有对这些数字工具的心理测量属性的全面概述.
研究的目的:
- 进行范围审查,确定智能手机和平板电脑基于认知工具的质量特征报告.
- 专注于在临床前AD或MCI患者中适合远程管理的工具.
- 评估心理测量属性和实际工具特征.
主要方法:
- 从2008年到2023年,在四个数据库 (PubMed,Embase,Web of Science,PsycINFO) 进行系统的文献搜索.
- 包括评估数字认知工具远程使用在临床前AD或MCI中的心理特性的研究.
- 选和数据提取由两个独立审查员根据PRISMA-ScR指南进行.
主要成果:
- 包括50项描述37种数字工具的研究.
- 大多数工具 (97%) 报告了构造有效性,但关于结构有效性 (8%),测试复试可靠性 (32%),响应性 (16%),临床意义 (0%) 的信息有限.
- 大多数工具在患有MCI的个体中进行了测试 (92%),在临床前AD中较少 (22%).
结论:
- 许多用于早期AD认知评估的数字工具正在出现,但它们的心理测量验证往往不足.
- 虽然最初的验证步骤是常见的,但需要进一步严格的评估.
- 通过心理测量合理的结果证明临床有用性对于成功实施至关重要.
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