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使用手术前fMRI预测左叶手术后的记忆衰退:一项多中心研究

William L Gross¹, Sara J Swanson², Alexander I Helfand³

¹Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, United States; Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, United States.

NeuroImage. Clinical

|May 27, 2025

概括

功能性MRI (fMRI) 语言横向性可以预测手术后口头记忆的下降. 这项研究证实了fMRI.

科学领域:

神经科学是一个神经科学.
发病学 (Epileptology) 是一个专业的学科.
医疗成像医学成像

背景情况:

在手术后预测口头记忆的下降对于患者咨询至关重要.
功能性MRI (fMRI) 语言横向性是一种潜在的预测因素,但证据尚未确定.
该FATES项目旨在验证fMRI在多中心队列中的预测能力.

研究的目的:

确定包括fMRI语言横向性的多变量模型是否可以预测左叶手术后6个月的口头记忆结果.
评估fMRI语言横向性指数 (LI) 对预测记忆变化的独立贡献.

主要方法:

在10个美国中心进行前性观察队列研究.
70名成年人接受左叶手术,并进行海马切除.
使用语义决策与音调决策 (SDTD) 任务进行手术前fMRI语言映射.
多重线性回归分析包括手术前记忆,持续时间,年龄,海马硬化和fMRI SDTD LI.

主要成果:

在五种记忆测量方法中,在8%-28%的患者中观察到口头记忆的下降.
所有记忆测量的变化与手术前得分,持续时间和fMRI SDTD LI有显著的相关性.
fMRI LI独立地占记忆变化变异的7%-25% (p <0.05).

结论:

从SDTD任务中结合fMRI语言LI的模型有意义地预测左叶手术后口头记忆的下降.
这些基于fMRI的协议在实施和帮助患者了解手术风险方面具有实用性.
证实了以前的证据支持使用fMRI来预测术后的口头情节性记忆结果.

关键词:

的手术手术是在.语言侧面性语言侧面性时间叶发作时间叶.语言记忆语言记忆

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