针对氧化应激介导调节细胞死亡作为癌症的脆弱性
Danyao Chen1, Ziyu Guo2, Lei Yao3
1Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China; National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, China; Furong Laboratory, Changsha, Hunan, China; Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, China; Department of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
活性氧物种 (ROS) 对细胞功能至关重要,但它们在癌症中的不平衡可以被利用. 本综述探讨了针对ROS介导调控细胞死亡 (RCD) 作为癌症治疗的向.
科学领域:
- 细胞生物学 细胞生物学
- 在瘤学瘤学.
- 生物化学 生物化学
背景情况:
- 反应性氧物种 (ROS) 是细胞过程的关键调节者,维持氧化还原平衡.
- 瘤细胞表现出氧化还原失衡,其中ROS可以根据度促进或抑制癌症.
- 向ROS介导调控细胞死亡 (RCD) 具有潜在的癌症脆弱性.
研究的目的:
- 提供ROS生产,控制及其在癌症中的作用的全面概述.
- 探索RCD中ROS的复杂调节及其治疗应用.
- 讨论针对癌症治疗的ROS介导RCD的挑战和未来前景.
主要方法:
- 对ROS,氧化还原平衡和癌细胞死亡的现有文献进行系统审查.
- 分析癌细胞中的ROS信号通路和交叉连接网络.
- 评估目前和潜在的治疗策略,以ROS介导的RCD为目标.
主要成果:
- ROS在癌症中起着双重作用,在低水平上促进瘤发生,在高水平上诱导RCD.
- 复杂的调节网络控制癌症中ROS介导的细胞死亡.
- 针对特定的氧化还原平衡机制显示出药物开发的前景.
结论:
- 了解ROS动态对于癌症治疗的发展至关重要.
- 针对ROS诱导的RCD提供了一个有前途的治疗策略.
- 需要进一步的研究来克服测量ROS和临床应用这些疗法的挑战.
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