口腔和皮肤微生物群对多发性硬化症风险和严重性的影响:孟德尔的随机化分析
Valeria Zancan1, Martina Nasello1, Selene Diamant1
1Department of Neurosciences, Mental Health and Sensory Organs, Sapienza University of Rome, Rome, Italy.
Multiple sclerosis and related disorders
|May 27, 2025
概括
皮肤微生物组,特别是Veillonella属,可能会增加多发性硬化症 (MS) 的风险. 皮肤和口腔微生物似乎也影响了MS的严重程度,这表明除了肠道之外,dysbiosis的作用更广泛.
科学领域:
- 微生物组研究 微生物组研究
- 神经免疫学 神经免疫学
- 人类遗传学 人类遗传学
背景情况:
- 广泛的研究将肠道微生物群与多发性硬化症 (MS) 联系起来.
- 口腔和皮肤微生物组在多发性硬化症发病过程中的作用仍未得到充分研究.
- 了解肠外微生物贡献对于全面了解MS至关重要.
研究的目的:
- 调查口腔和皮肤微生物组合与MS风险之间的因果关系.
- 评估口腔和皮肤微生物群落与MS严重程度之间的关联.
- 探索肠外异位症在MS病因学中的潜在作用.
主要方法:
- 两个样本的孟德尔随机化 (MR) 分析利用大型全基因组关联研究 (GWAS) 总结统计数据.
- 来自GWAS的口腔和皮肤微生物组合的暴露数据.
- 来自GWAS的MS易感性和严重性的结果数据;使用反变量加权 (IVW) 和沃尔德比率进行初级分析,并使用MR-Egger进行变性评估.
主要成果:
- 皮肤细菌*Veillonella*属的相对丰富性显示出与增加多发性硬化症风险的潜在关联.
- 皮肤微生物群,特别是Gammaproteobacteria类,与MS严重程度有关.
- 观察到口腔微生物的保护性关联,包括Bacilli类,Porphyromonas*属,Proteobacteria类和Veillonella dispar*.
结论:
- 皮肤微生物群的组成可能会增加患多发性硬化症的风险.
- 口腔和皮肤微生物群落似乎都影响了MS疾病的严重程度.
- 这些发现扩大了对MS中微生物失生症的理解,超越了肠道.
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