阴道的结节阳性癌症用治疗意图的放射疗法治疗
Julianne O'Shea1, Emma Link2, Pearly Khaw3
1Peter MacCallum Cancer Centre, Department of Radiation Oncology, Melbourne, VIC, Australia.
概括
手术后的放射治疗为结节阳性癌患者提供了最好的结果. 绝对化疗是那些无法接受手术的人的可行替代方案.
科学领域:
- 妇科瘤学 妇科瘤学
- 辐射瘤学 辐射瘤学
- 医学瘤学 医学瘤学
背景情况:
- 阳性节点性阴道癌在治疗和预后方面存在重大挑战.
- 放射治疗,有或没有化疗,是管理癌的基石.
研究的目的:
- 为了评估治疗结节阳性癌患者的治疗结果,这些患者接受放射治疗 (有或没有化疗) 以治愈的意图.
- 分析第一次失败的模式,局部区域控制和整体存活率.
主要方法:
- 在2000年至2019年期间接受治疗的88名节点阳性癌患者的回顾性分析.
- 患者接受了辅助放射治疗 (有或没有化疗) 的手术或最终的化疗放射治疗.
- 从前数据库系统地收集临床,组织病理学,治疗和随访数据.
主要成果:
- 辅助手术组的五年总生存率为62%,绝对化疗放射治疗组为50%.
- 5年后的局部区域控制是辅助组的64%,最终组的49%.
- 最常见的失败模式是孤立的初级部位复发 (35%的复发).
结论:
- 手术后的辅助放射治疗在节点阳性癌中产生了优异的局部区域控制和整体存活率.
- 绝对化疗是不适合手术的患者的有价值的替代治疗方法,提供适度的疾病控制和生存益处.
更多相关视频
04:25Author Spotlight: Dermatopathology and the Treatment of Sexually Transmitted Diseases
Published on: November 8, 2024
1.9K
04:04Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
10.6K
相关概念视频
Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
Cancer Therapies
8.0K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.0K
