加速度计测量身体活动与癌症幸存者的死亡率之间的关联:英国生物银行的一项前性队列研究
Zhihan Jiang1, Bingyan Wang1, Yifei Zhao1
1Department of General Surgery, Peking University Third Hospital, Peking University, Beijing 100191, China; Beijing Key Laboratory for Interdisciplinary Research in Gastrointestinal Oncology (BLGO), Beijing 100191, China.
The journal of nutrition, health & aging
|May 27, 2025
概括
参与中等到剧烈的体力活动显著降低了癌症幸存者的死亡风险. 益处在较高的活动水平时最为明显,特别是在癌症特异性死亡率方面.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 身体活动研究 身体活动研究
背景情况:
- 诊断后的身体活动对于癌症幸存者的福祉至关重要.
- 可穿戴的加速度计提供对身体活动强度和持续时间的客观测量.
研究的目的:
- 研究癌症幸存者体育活动强度和持续时间与死亡率之间的关联.
- 探索体力活动与全因和癌症特异性死亡率之间的剂量反应关系.
主要方法:
- 来自英国生物银行的11,708名癌症幸存者的前性队列研究.
- 使用手腕穿戴的加速度计对身体活动的客观测量.
- 使用限制立方线和考克斯比例危险模型进行分析.
主要成果:
- 在中度到强烈强度的体力活动 (MVPA) 和降低死亡率之间发现了显著的剂量反应关联.
- 较高的MVPA持续时间 (≥579分/周) 与所有原因和癌症特异性死亡率的大幅降低有关.
- 对中等强度活动观察到好处,但对光强度活动没有;在各种癌症类型中观察到生存优势.
结论:
- 适度至剧烈的体力活动大大降低了癌症幸存者的全因和癌症特定死亡率.
- 身体活动的强度是一个关键因素,只有在中度至强度水平时才有显著的好处.
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