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肠道微生物酶和与代谢功能障碍相关的脂肪肝炎:功能,机制和治疗前景
Xi Luo1, Kai Wang2, Changtao Jiang3
1Department of Physiology and Pathophysiology, Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing 100191, China.
与代谢功能障碍相关的脂肪性肝病 (MASLD) 涉及肠道微生物及其酶. 这些微生物通过改变代谢物和肠道屏障功能来影响肝脏健康,从而影响疾病的进展.
科学领域:
- 胃肠病学 胃肠病学
- 肝病学 肝病学是一种肝病学.
- 微生物学 微生物学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个全球性的健康问题.
- 肠道微生物群及其酶在肝脏疾病的发病过程中起着至关重要的作用.
- 失生症和改变的微生物酶有助于MASLD和MASH的进展.
研究的目的:
- 阐明肠道微生物群和微生物酶在MASLD和MASH中的作用.
- 了解微生物代谢物和改变的肠道屏障功能如何影响肝脏疾病.
主要方法:
- 目前关于肠道微生物群,微生物酶和MASLD/MASH的文献的综述.
- 分析受微生物酶影响的代谢途径.
- 检查肠道屏障完整性对肝炎和纤维化的影响.
主要成果:
- 微生物酶是代谢类固醇,脂肪酸,氨基酸,乙醇和胆的核心,影响MASLD/MASH.
- 肠道失生症损害了肠道屏障,增加了肝脏对微生物产品的暴露.
- 改变肠道微生物群信号影响肝脏新陈代谢和疾病严重程度.
结论:
- 肠道微生物群和微生物酶是MASLD和MASH的关键驱动因素.
- 针对特定的肠道微生物或酶提供了个性化MASLD/MASH疗法的潜力.
- 了解这些相互作用对于开发新的治疗策略至关重要.
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