核心级别6:在发现表的总结中提出证据
Gordon Guyatt1,2,3, Liang Yao4, M Hassan Murad5
1Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada guyatt@mcmaster.ca.
BMJ (Clinical research ed.)
|May 27, 2025
概括
这篇文章详细介绍了核心GRADE方法的总结结果表,这对于理解干预效应和证据确定性至关重要. 这些表格呈现了相对和绝对效应,有助于临床决策对患者的结果.
科学领域:
- 临床证据综合研究
- 卫生技术评估 卫生技术评估
- 基于证据的医学基于证据的医学.
背景情况:
- 结论摘要 (SoF) 表对于展示干预效应的证据至关重要.
- 建议评估,开发和评价 (GRADE) 方法的分级为评估证据质量提供了一个框架.
- 准确地解释干预效应需要明确地阐述绝对和相对风险以及证据的确定性.
研究的目的:
- 介绍核心GRADE方法,用于构建结论表的总结.
- 为二进制和连续结果概述展示绝对和相对效应的方法.
- 提高患者重要结果的证据的清晰度和可解释性.
主要方法:
- 描述核心GRADE方法,用于开发结论表的摘要.
- 解释使用对二元结果的基线风险计算绝对效应的计算.
- 应对呈现连续结果的挑战,包括不同的测量仪器和最小重要的差异.
主要成果:
- 结果表的摘要提供了干预效应的基本信息,包括相对和绝对效应以及证据的确定性.
- 对于二进制结果,使用相对风险估计和代表性基线风险来计算绝对效应.
- 结论表总结中的单独行包含不同的基线风险,单位和最小重要的差异的细节有助于持续的结果解释.
结论:
- 核心GRADE方法有助于创建信息总结的调查结果表.
- 这些表格提高了对干预效应的理解,并提高了对患者结果的证据确定性.
- 清晰地呈现绝对效应和结果测量细节,提高了证据在临床实践中的适用性.
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