在非肌肉侵入性膀癌中进行过尿道切除后短期连续盐水灌的随机研究
Takehisa Onishi1, Sho Sekito2, Takuji Shibahara2
1Department of Urology, Ise Red Cross Hospital, Ise, Japan; iseredcrossuro@gmail.com.
Anticancer research
|May 27, 2025
概括
短期连续盐水膀灌 (S-CSBI) 与长期的CSBI (L-CSBI) 在预防 TURBT后膀瘤复发方面同样有效. 这一发现支持S-CSBI作为非肌肉侵入性膀癌患者的可行选择.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 手术创新 在外科创新.
背景情况:
- 膀瘤通过尿道切除 (TURBT) 是治疗非肌肉侵入性膀癌 (NMIBC) 的标准程序.
- 持续盐水膀灌 (CSBI) 经常用于TURBT后,以预防并发症.
- CSBI的最佳持续时间 (短期与长期) 需要调查.
研究的目的:
- 在NMIBC患者中,比较短期连续盐水膀灌 (S-CSBI) 与长期CSBI (L-CSBI) 在TURBT后的疗效和安全性.
- 根据2年无复发生存率 (RFS) 来评估S-CSBI与L-CSBI的非劣势.
主要方法:
- 一项随机试验,在2016-2021年期间,涉及323名怀疑患有初级NMIBC的患者.
- 患者接受了TURBT后的3小时S-CSBI或一夜间L-CSBI.
- 排除标准包括高风险的NMIBC和肌肉侵入性膀癌.
主要成果:
- 在S-CSBI和L-CSBI组中,两年无复发生存率为70.5%.
- 证实S-CSBI不低于L-CSBI,符合预定义的不低劣差额.
- 没有发现严重的全身毒性;S-CSBI组的血IIIa级略高,但在统计学上没有显著意义.
结论:
- 在NMIBC中,短期连续盐水膀灌 (S-CSBI) 在NMIBC中 TURBT后的2年无复发生存期与长期CSBI (L-CSBI) 不相差.
- S-CSBI提供了一种实用且潜在的优势替代方案,特别是在日间手术场所.
- 对于接受NMIBC的TURBT患者来说,S-CSBI是一个可行的治疗选择.
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