食补充剂对骨关节炎患者的影响:系统性审查和网络元分析
Chang-Shun Chen1, Lei Wen1, Fei Yang2
1Department of Orthopedics and Trauma Surgery, Affiliated Hospital of Yunnan University, Kunming 650032, Yunnan Province, China.
Journal of integrative medicine
|May 27, 2025
概括
激情果皮提取物和兰科诺恩在改善骨关节炎疼痛和功能方面表现有前途. 需要进一步的研究来证实这些食补充剂的有效性.
科学领域:
- 骨关节炎研究 骨关节炎研究
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 越来越多的人对非药物治疗关节炎的兴趣越来越大,特别是抗氧化和抗炎性食补充剂.
- 关于患者用于骨关节炎管理的补充剂实际有效性的不确定性.
研究的目的:
- 综合评估各种食补充剂在关节炎治疗中的疗效的证据.
- 确定最佳的食补充剂,以改善骨关节炎患者的疼痛和功能.
主要方法:
- 在PubMed,Embase,Cochrane图书馆和Web of Science的系统文献搜索到2025年1月20日.
- 包括随机对照试验 (RCT),比较骨关节炎患者的食补充剂与安慰剂.
- 使用累积排名曲线下的表面 (SUCRA) 来获取和分析疼痛和功能得分的数据,用GRADE评估证据质量.
主要成果:
- 分析了23项涉及21种食补充剂和2455名参与者的研究.
- 激情果皮提取物在WOMAC疼痛 (91%) 和功能 (99%) 评分上表现为最高的SUCRA.
- 排名最高的补充剂包括激情果皮提取物,兰科农和原蛋白,但整体证据质量较低.
结论:
- 激情果皮提取物成为改善骨关节炎疼痛和功能的最有效补充剂,其次是兰科和原蛋白.
- 这些发现表明特定食补充剂的潜在益处,但证据质量较低需要谨慎.
- 进一步的大规模,精心设计的RCT对于验证这些有希望的结果和确认补充剂在关节炎管理中的有效性至关重要.
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