在老年患有膀癌的成年人中,类风湿关节炎,虚弱状态和死亡率之间的关联
Maya Swaminathan1, Sarah K Holt2, John L Gore2
1Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA.
Clinical genitourinary cancer
|May 27, 2025
概括
类风湿性关节炎 (RA) 增加了患有膀癌的非脆弱老年人死亡风险. 然而,虚弱似乎减少了RA对生存的影响,这表明虚弱的影响可能更为主导.
科学领域:
- 老年学是一门学科.
- 在瘤学瘤学.
- 类风湿病学 类风湿病学
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性疾病,影响着老年人.
- 膀癌的存活率可能会受到并发症和患者虚弱的影响.
- 了解RA,虚弱性和膀癌死亡率之间的相互作用至关重要.
研究的目的:
- 为了研究类风湿性关节炎 (RA) 与所有原因死亡率 (ACM) 和癌症特异性死亡率 (CSM) 之间的联系,在患有膀癌的老年人中.
- 为了检查脆弱性对这种人群中RA死亡率关系的修改效应.
主要方法:
- 一项回顾性队列研究,使用2004-2017年的SEER-Medicare数据.
- 包括65岁以上被诊断患有膀癌的患者.
- 使用行政算法确定RA和脆弱状态;来自SEER注册表的死亡数据.
主要成果:
- 脆弱性显著改变了RA和死亡结果之间的关联 (Pinteraction < .01).
- 在非脆弱患者中,RA与更高的CSM (aHR 1.17) 和ACM (aHR 1.12) 相关.
- 在脆弱患者中,RA与CSM (aHR 0.81) 或ACM (aHR 0.93) 没有独立相关.
结论:
- 虚弱是影响老年人健康状况的一个重要因素.
- 在非脆弱的老年人中,RA与膀癌的死亡风险增加有关.
- 在脆弱的个体中,脆弱对死亡率的影响可能会超过RA的影响,有助于预测结果.
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