2001年至2021年墨西哥老年人认知功能的队列变化
Julián Ponce1, Hiram Beltrán-Sánchez1,2
1Department of Community Health Sciences, Fielding School of Public Health, University of California Los Angeles (UCLA), Los Angeles, California, USA.
The Gerontologist
|May 27, 2025
概括
墨西哥的老年人在最近的队伍中经历了较慢的认知衰退. 多种疾病多重症.
科学领域:
- 老年学是一门学科.
- 认知神经科学 认知神经科学
- 公共卫生 公共卫生
背景情况:
- 多病症,定义为有两个或两个以上的慢性疾病,与老年人加速认知衰退有关.
- 在墨西哥等低收入和中等收入国家,关于认知衰退和多病症的纵向数据很少.
研究的目的:
- 调查墨西哥老年人的认知衰退年率的队列差异.
- 为了确定多病症和认知衰退之间的关联是否在两个不同的出生队伍之间有所不同.
主要方法:
- 对两个10年出生队列 (队列1: 1941-1951;队列2: 1952-1962) 的分析,基线年龄为50-60.
- 每个队列在10年时间内进行了三次数据收集 (队列1: 2001,2003,2012;队列2: 2012,2015,2021).
- 使用增长曲线模型来评估全球认知功能得分 (GCFS) 和队列差异的年度变化.
主要成果:
- 较早的队列 (第1队列,2001年基线) 与较晚的队列 (第2队列2012年基线) 相比,表现出显著更快的认知衰退 (GCFS) 年平均速度.
- 在控制潜在的混因素时,多病症和认知衰退率之间的关联在两个队列之间没有显著差异.
结论:
- 在较新的队列中观察到的较慢的认知衰退表明,提高教育成就和增强认知储备可能会带来潜在的好处.
- 近几十年来,医疗保健获得的改善可能已经减轻了多病症对认知功能的不良影响,这解释了这一关联中缺乏队列差异.
- 这些发现突显了认知衰老的不断变化的模式以及多病症在墨西哥人口中的影响.
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