多发性硬化症患者的个性特征:系统性审查和元分析
Omid Mirmosayyeb1, Mohammad Yazdan Panah2, Saeed Vaheb2
1Department of Neurology, Jacobs Comprehensive MS Treatment and Research Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.
The Clinical neuropsychologist
|May 27, 2025
概括
患有多发性硬化症 (PwMS) 的人表现出明显的个性特征,与健康对照人群相比,神经病症更高. 这些特征,特别是神经症和良心,与PwMS的情绪,疲劳,认知功能和残疾有关.
科学领域:
- 神经学 神经学
- 心理学 心理学 心理学
- 精神病学是一个精神病学.
背景情况:
- 多发性硬化症 (MS) 是一种慢性神经系统疾病,影响着全世界数以百万计的人.
- 了解多发性硬化症 (PwMS) 患者的心理形象对于全面的护理至关重要.
- 之前在PwMS中关于人格特征的研究是分散的,需要进行综合分析.
研究的目的:
- 系统地审查和元分析PwMS中关于人格特征的现有文献.
- 为了比较PwMS的人格特征与健康对照 (HCs).
- 在PwMS中调查人格特征与情绪,认知,疲劳和身体功能等关键结果之间的相关性.
主要方法:
- 在2024年8月18日之前,对主要数据库 (PubMed/MEDLINE,Scopus,Embase,Web of Science) 进行系统搜索.
- 包括在PwMS和HC之间比较个性特征 (可取,良心,外向,神经,开放) 的研究.
- 在PwMS中包括评估人格特征与焦虑,抑郁,认知,疲劳和身体功能之间的相关性研究.
主要成果:
- 分析了63项涉及8068名PwMS和1588名HC的研究.
- 与HC相比,PwMS表现出显著更高的神经病变 (SMD = 0.35) 与HC相比.
- 神经症与增加的焦虑 (r=0.78),抑郁 (r=0.53) 和疲劳 (r=0.35) 强烈相关.
- 良心与减少残疾 (EDSS,r=-0.21) 和更好的认知表现 (SDMT,r=0.13) 相相关.
结论:
- 患有多发性硬化症的人表现出独特的个性特征,其特征是神经病症升高.
- 人格特征,特别是神经病症和良心,与MS患者的心理健康,疲劳和功能状态有显著的关联.
- 这些发现强调了在综合性硬化症的整体管理中考虑个性的重要性.
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