身体到大脑的胰岛素和Notch信号通过神经元CREB活动调节记忆
Shiyi Zhou1,2, Katherine E Novak1,2, Rachel Kaletsky1,2
1Department of Molecular Biology, Princeton University, Princeton, NJ, USA.
身体的信号会影响记忆. 皮下体中的胰岛素信号通过激活神经元的Notch信号和CREB来调节记忆持续时间,揭示了新陈代谢和记忆之间的系统联系.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 分子生物学分子生物学
背景情况:
- 记忆调节主要被认为是一种神经元过程.
- 胰岛素/IGF-1类信号传递 (IIS) 途径影响C. elegans的寿命,新陈代谢和记忆.
- 长寿的DAF-2突变体的记忆时间翻了一番,这表明神经元的控制.
研究的目的:
- 研究影响记忆调节的非神经元因素.
- 阐明连接新陈代谢和记忆的系统机制.
- 探索皮下信号在记忆中的作用.
主要方法:
- 在Caenorhabditis elegans hypodermis中DAF-2的遗传操纵.
- 分析神经元中的OSM-11连接体表达和Notch信号激活.
- 神经元的单核RNA测序以评估基因表达.
- 评估老年动物的记忆和学习能力.
主要成果:
- 皮下DAF-2降解显著延长记忆的持续时间.
- 这种效应是由可扩散的诺奇配体OSM-11介导的,激活神经元诺奇信号传递.
- 神经元CREB和其他记忆基因表达增加.
- 皮下IIS-Notch通路的激活和OSM-11过度表达通过CREB拯救老年动物的记忆和学习.
结论:
- 低皮层中的胰岛素信号非自主调节神经元记忆.
- 一个系统性的IIS-Notch-CREB信号通路将身体的新陈代谢与神经元功能和记忆联系起来.
- 这一途径提供了一种系统调节记忆和学习的机制.
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