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Updated: Sep 20, 2025

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
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帕瑟诺利德通过抑制ZNF207/BUGZ促进的kinetochore-microtubule附着来破坏线粒分裂

Susana Eibes1, R Bhagya Lakshmi1, Girish Rajendraprasad1

  • 1Cell Division and Cytoskeleton, Danish Cancer Institute, Copenhagen, Denmark.

The EMBO journal
|May 27, 2025
PubMed
概括

帕特诺利德是一种天然的抗癌化合物,通过与kinetochore中的BUGZ蛋白结合来破坏细胞分裂. 这阻止了染色体正确地附着在线索上,揭示了一种新的抗真菌机制.

关键词:
这是一个BUGZBUGZ.在Kinetochore中进行演出.这些微管是微管子.线粒分裂 (mitosis) 是一种发生在细胞间的过程.帕瑟诺利德是什么类型的

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