在COVID后的时代,成年人中Streptococcus pyogenes细菌病的趋势在变化
Olga Džupová1,2, Hynek Bartoš3,4, Blanka Sýkorová5
1Third Faculty of Medicine, Charles University, Prague, Czech Republic. olga.dzupova@lf3.cuni.cz.
BMC infectious diseases
|May 27, 2025
概括
成年人中的侵袭性A组链球菌 (iGAS) 感染在流行病后增加,病例更严重,死亡率更高. 这项研究比较了COVID-19大流行之前和之后的IGAS感染.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 微生物学 微生物学
背景情况:
- 自2022年以来,已观察到侵袭性A型 estreptococcal (iGAS) 感染的增加,其特点是严重程度和致死性增加.
- COVID-19 流行病可能影响了iGAS 感染的流行病学和临床表现.
研究的目的:
- 为了比较在COVID-19大流行之前和之后的成年人中细菌性A组链球菌 (GAS) 感染的频率和临床特征.
- 为了识别患者人口统计,临床表现,治疗反应和结果的变化.
主要方法:
- 使用了回顾性观察性研究设计.
- 在两个不同的时期分析了被诊断患有Streptococcus pyogenes细菌病的成年患者:大流行前 (2017年1月至2019年12月) 和大流行后 (2022年10月至2023年12月).
- 收集的数据包括人口统计,临床表现,抗生素治疗,治疗反应,并发症和患者结果.
主要成果:
- 这项研究比较了35个流行前病例和36个流行后病例.
- 流行后组显示女性比例较高 (67%vs. 31%),并显著增加了败血症休克 (56%vs. 26%).
- 虽然总体死亡率没有显著差异,但流行病后的年死亡人数增加了三倍以上,观察到肺炎和脑膜炎等罕见表现.
结论:
- 在大人的细菌性GAS感染在流行病后的时期显著增加.
- 观察到的关键变化包括受影响的女性比例更高,性别年龄分布的变化,罕见的临床表现的出现和治疗反应较差.
- 这些发现表明,流行后成人GAS疾病的严重程度增加,每年死亡人数增加.
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