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The pancreas, an essential organ in the human body, is a pinkish-gray elongated structure located posterior to the stomach. It extends laterally from the duodenum towards the spleen and is firmly bound to the posterior wall of the abdominal cavity. The organ's surface has a lumpy, lobular texture that gives it a unique appearance.
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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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在拉丁美洲计划中,超过1000例胰腺移植.

Marcelo Perosa1, Juan R Branez1, Fernanda R Danziere1

  • 1Pancreas and Kidney Transplant Program, Leforte Hospital, São Paulo, Brazil.

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概括

胰腺移植 (PT) 是1型糖尿病的重要治疗方法. 这项研究表明,一个大规模的巴西计划在25年内实现了优异的患者存活率和减少并发症.

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科学领域:

  • 脏病学和内分泌学
  • 移植手术 移植手术
  • 免疫学 免疫学 免疫学

背景情况:

  • 胰腺移植 (PT) 有效治疗末期病或脆性糖尿病的1型糖尿病.
  • 最近,全球PT量和高量计划的数量有所下降.
  • 这项研究分析了来自巴西大量PT项目25年的经验.

研究的目的:

  • 分析了1996年至2021年期间进行的1000多次胰腺移植的结果.
  • 评估手术技术和免疫抑制方案的演变.
  • 评估高体积环境中的患者和移植存活率.

主要方法:

  • 对1073个PTs的回顾性分析:593个同时胰腺-脏 (SPK) 和480个单独的PTs (331个PAK,149个PTA).
  • 根据手术技术,移植被分为三个阶段 (全身膀到门肠,门肠-双肠,全身肠).
  • 标准免疫抑制剂: 胸球蛋白, 塔克罗利, 菌酸/, 和类固醇.

主要成果:

  • 患者的整体1年存活率超过了初级PTA/PAK的90%,SPK/PRT的85%.
  • 一年死亡审查的移植存活率为97% (SPK-脏),90% (SPK-胰腺) 和75% (单独的PT).
  • 随着时间的推移,冷缺血时间和胰腺血栓的显著减少 (SPK下降到2%).

结论:

  • 巴西PT计划维持了25年的高体积活动.
  • 该计划已成为世界上最活跃的项目之一,每年执行超过60次PT.
  • 手术技术的进化和优化方案有助于改善结果.