多发性硬化症患者的性功能:系统性审查和元分析
Mohammad Yazdan Panah1,2, Soroush Oraee3, Mehra Fekri3
1Student Research Committee, Shahrekord University of Medical Sciences, 88157-13471 Shahrekord, Iran.
The journal of sexual medicine
|May 28, 2025
概括
性功能障碍在患有多发性硬化症 (PwMS) 的人群中很常见,影响生活质量. 这次审查证实,与健康人相比,PwMS患者的性功能下降,与残疾和抑郁症有关.
科学领域:
- 神经学 神经学
- 性医学性医学性医学性医学
- 生活质量研究 研究 生命质量研究
背景情况:
- 性功能障碍 (SF) 是患有多发性硬化症 (PwMS) 的人群中普遍存在且具有影响力的问题.
- 了解在PwMS中影响SF的因素对于改善他们的整体福祉至关重要.
研究的目的:
- 系统地审查和综合比较PwMS中的性功能与健康对照 (HCs) 的证据.
- 调查性功能与人口统计,临床和心理因素之间的相关性.
主要方法:
- 在主要数据库 (PubMed/MEDLINE,Embase,Scopus,Web of Science) 进行了系统的文献搜索,截至2024年7月.
- 使用随机效应模型的元分析被用来计算聚合的标准化平均差异和相关性.
主要成果:
- 分析包括61项研究,涉及16,266名PwMS,显示PwMS的SF相比HCs显著减少.
- 患有MS的女性 (FwMS) 显示女性性功能指数得分较低 (SMD: -0.41),患有MS的男性 (MwMS) 显示国际勃起功能指数得分较低 (SMD: -0.77).
- 减少SF与更高的扩展残疾状态量表 (EDSS) 评分,更长的疾病持续时间,抑郁和疲劳相关,特别是在FwMS中.
结论:
- 与HC相比,PwMS中的性功能明显较低.
- 年龄,疾病持续时间,抑郁症和EDSS是PwMS中SF的重要影响因素.
- 建议进行进一步的研究,以探索并发症,药物和MS分类对PwMS中的SF的影响.
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