生命历程暴露于菌和肌缩性侧面硬化症生存率
Stuart A Batterman1, Md Kamrul Islam1, Dae Gyu Jang2,3
1Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
概括
菌有害藻类繁殖 (cyanoHABs) 暴露可能会影响肌缩侧面硬化症 (ALS) 的存活率. 居住在花附近与更短的存活率有关,这表明一种新的,潜在的可修改的ALS风险因素.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
背景情况:
- 菌有害藻类繁殖 (cyanoHABs) 是全球性的,并通过暴露于毒素带来风险.
- 肌缩侧面硬化症 (ALS) 是一种具有复杂病因的进展性神经退行性疾病.
- 现有的研究缺乏可靠的方法来量化对酸的长期环境暴露.
研究的目的:
- 开发和验证对蓝菌的终身暴露措施.
- 为了研究估计的cyanoHAB暴露和ALS生存率之间的关联.
- 确定影响ALS进展的潜在环境风险因素.
主要方法:
- 利用个人居住史,ALS发病日期和卫星数据 (蓝菌评估网络).
- 根据居住时间和距离 (0.25-10公里) 与含有蓝色HABs的水体的距离,开发了加权的暴露指标.
- 评估了各种指标,缓冲区大小 (2.5-5公里) 和相对于疾病发病的暴露窗口.
主要成果:
- 大多数参与者在其一生中都生活在色HAB的5公里范围内.
- 增加的cyanoHAB暴露与高达0.89年更短的ALS存活率有关.
- 对于参与游泳,鱼或使用私人井的人来说,观察到显著的相互作用.
结论:
- 为人口研究开发了新的,空间和时间解析的酸暴露测量方法.
- 研究结果表明,暴露于cyanoHAB是潜在的,可修改的ALS生存风险因素.
- 强调需要进一步的研究来证实这些关联,并探索与其他神经退行性疾病的联系.
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