多营养牛奶强化对早产新生儿结果的影响:一个网络元分析
Marsha Campbell-Yeo1,2, Courtney Gullickson3, Holly McCulloch2
1School of Nursing, Dalhousie University, Halifax, NS B3H 4R2, Canada.
Nutrients
|May 28, 2025
概括
对早产婴儿的最佳食方案仍然不清楚. 含有特定强化剂的母乳对某些结果有好处,但需要更多的研究来确认早产新生儿的最佳方法.
科学领域:
- 新生儿营养新生儿营养
- 儿科胃肠病学 儿科胃肠病学
- 临床营养学 临床营养学
背景情况:
- 对于早产新生儿,最佳的食方案还没有很好地定义.
- 对于早产婴儿食中的多营养强化,实践中存在差异.
- 不同的强化养方案对早产婴儿结果的影响需要澄清.
研究的目的:
- 为了比较各种养方案,包括多营养强化,为早产婴儿.
- 评估不同养策略对关键新生儿结果的影响.
- 提供关于早产婴儿营养干预措施的全球概述.
主要方法:
- 网络元分析的设计.
- 在2023年6月27日之前对Cochrane CENTRAL,Medline,Embase和CINAHL的系统文献搜索.
- 包括随机临床试验的早产婴儿食方案与多营养强化.
主要成果:
- 母乳与捐赠者奶以及基于人乳的强化剂的母乳在死亡率,死性肠球炎 (NEC) 和全肠养时间方面排名最高.
- 含有强化剂的母乳对早产视网膜病变 (ROP) 和支气管肺功能障碍 (BPD) 是最佳的.
- 不同的治疗方案显示出毒症,周周结膜性白血病 (PVL) 和发育评分 (贝利II MDI) 的不同排名.
结论:
- 增加母乳摄入量与早产婴儿的更好的临床结果有关.
- 这次审查强调,没有足够的高质量的证据来最终推一种强化养方案而不是另一种强化养方案.
- 需要进一步的研究,以建立最佳的多营养强化策略,为早产新生儿.
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