作为急性和慢性心力衰竭死亡风险预测器的CONUT评分:一个元分析性审查
Diana Andreea Fărcaș1, Anda Cerghizan2,3, Raluca Maior4
1Emergency Institute for Cardiovascular Diseases and Transplantation of Târgu Mureș, 540136 Târgu Mureș, Romania.
Nutrients
|May 28, 2025
概括
控制营养状况 (CONUT) 评分有效预测心力衰竭患者的死亡风险. 较高的CONUT分数表明,在急性和慢性心力衰竭中,全因死亡风险更高.
科学领域:
- 心脏病学 心脏病学
- 营养科学 营养科学
- 生物统计学 生物统计学
背景情况:
- 心力衰竭 (HF) 是一个重大的全球健康挑战,影响了发病率和死亡率.
- 营养状况越来越被认为是HF患者结果的关键决定因素.
- 控制营养状况 (CONUT) 评分提供了一种简单,客观的方法来评估使用白蛋白,胆固醇和淋巴细胞水平的营养状况.
研究的目的:
- 评估CONUT得分在预测急性和慢性心力衰竭患者全因死亡率方面的预后能力.
- 通过元分析综合现有证据,确定CONUT得分与HF群体死亡率之间的关联.
主要方法:
- 在主要数据库 (PubMed,MEDLINE,Google Scholar,Cochrane Library) 进行了系统的文献搜索,寻找过去十年内发表的研究.
- 关键词包括"心力衰竭"",CONUT分数"",营养不良"和"死亡率".
- 包括在内,符合条件的研究报告了成年HF患者与CONUT得分类别相关的全因死亡风险比率 (HRs). 分析了8项涉及15761名患者的研究.
主要成果:
- 分析显示,较高的CONUT分数与心力衰竭患者全因死亡率的增加之间存在显著的关联 (汇总HR=1.47;95%CI:1.30-1.66).
- 虽然观察到相当多的异质性 (I2 = 80%),但在所有纳入研究中,增加死亡率的趋势与更高的CONUT得分一致.
结论:
- CONUT评分作为急性和慢性心力衰竭的有价值的预后指标.
- 需要进一步的研究,以探索高风险的HF患者的营养干预措施,这些患者的CONUT分数较高.
- 建议在临床实践中标准化营养不良的截止值.
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