相关实验视频

Updated: Sep 20, 2025

Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System

Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System

Published on: October 5, 2015

在移植人群中治疗腺病毒感染:除了cidofovir之外的治疗选择?

Niyati Narsana¹, David Ha^2,3, Dora Y Ho³

¹Division of Infectious Diseases, UC Davis Medical Center, Sacramento, CA 95817, USA.

|May 28, 2025

概括

腺病毒感染对移植患者构成严重风险. 本综述检查了当前和新的治疗方法,强调了需要更好的疗法和标准化的协议管理腺病毒 (AdV) 在免疫功能低下的个体.

科学领域:

病毒学病毒学
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

腺病毒 (AdV) 感染在免疫功能低下的患者,特别是移植接受者中引起重大疾病和死亡.
目前的治疗方法,如cidofovir有局限性,包括可变的有效性和毒性.
现有的抗病毒药物 (利巴维林,甘西克洛维尔) 对抗AdV的疗效不一致.

研究的目的:

审查和评估针对腺病毒感染的现有和新兴疗法.
鉴定免疫受损人群的AdV管理中的挑战和未满足的需求.
突出改善治疗策略和进一步研究的需要.

主要方法:

对当前和新兴的AdV疗法进行系统审查.
对抗病毒药物和基于免疫的方法的临床数据的分析.
评估不同治疗方式的安全性和有效性.

主要成果:

与cidofovir相比,布林西多福维尔具有更好的安全性和体外功效.
采用T细胞疗法显示出病毒清除的潜力,但面临制造和安全障碍.
像利巴维林和甘西克洛维尔这样的现有疗法有效性有限.

结论:

对于AdV感染,有必要制定标准化治疗方案和进行比较研究.
个性化治疗方法和新型治疗剂对于有效的ADV管理至关重要.
需要进行进一步的研究,以解决腺病毒管理中未得到满足的临床需求.

关键词:

腺病毒的病毒.收养的T细胞疗法这是一个brincidoofovir.这就是cidofovir.甘西克洛维尔 (ganciclovir) 是一种药物.血液造血干细胞移植的结果是什么?利巴维林是一种利巴维林.实体器官移植实体器官移植

更多相关视频

Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus

Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus

Published on: May 7, 2012

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation

Published on: August 13, 2013

相关概念视频

Cystic Fibrosis: Management

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Subviral Agents

Subviral Agents

Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...