开发和验证CARRA-VID预后得分:C反应蛋白与白蛋白的比率,红细胞分布宽度和基于年龄的得分,用于预测住院COVID-19患者的预后
Marko Lucijanic1,2,3, Nevenka Piskac Zivkovic4,5, Nikolina Busic6
1Division of Hematology, Internal Medicine Department, University Hospital Dubrava, 10000 Zagreb, Croatia.
Viruses
|May 28, 2025
概括
一个新的CARRA-VID评分,使用C反应性蛋白与白蛋白比率 (CAR),红细胞分布宽度 (RDW) 和年龄,有效预测住院COVID-19患者的30天死亡率. 该工具将风险分为六类,以帮助临床决策.
科学领域:
- 临床医学 临床医学
- 传染性疾病 传染性疾病
- 生物标志物 生物标志物
背景情况:
- 住院的2019年冠状病毒病 (COVID-19) 患者经常表现出严重的症状和全身炎症.
- 已知C反应蛋白 (CRP),白蛋白和红细胞分布宽度 (RDW) 是COVID-19的预后标志物.
研究的目的:
- 开发和验证住院COVID-19患者30天死亡率的预后得分.
- 将CRP与白蛋白比率 (CAR),RDW和年龄整合到一个新的风险分层工具中.
主要方法:
- 对住院COVID-19患者的两大队列 (2305名和2328名患者) 的回顾性分析.
- 开发和验证CARRA-VID评分,评估其在不同病毒变体和疾病严重程度分类中的表现.
主要成果:
- 卡拉-维德评分确定了6个风险类别,30天死亡率从2.7%到89.7%不等.
- 风险分层仍然有效,独立于世卫组织的疾病严重程度和其他常见风险得分.
- 此外,还开发了一种简化的三级分数版本.
结论:
- 卡拉-维德得分为住院COVID-19患者的30天死亡率提供了强大的风险分层.
- 这一分数有助于识别针对性干预的高风险个体.
- 可提供用于CARRA-VID分数计算器的Microsoft Excel工作簿.
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