猪流行性腹病毒 (PEDV) 在美国引入后十年的当前进化动态
Joao P Herrera da Silva1, Nakarin Pamornchainavakul1, Mariana Kikuti1
1Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Viruses
|May 28, 2025
概括
猪流行性腹病毒 (PEDV) 的非S-INDEL菌株在美国占主导地位,目前的菌株在地理上受到限制,这表明传播有限,有助于重新引入风险评估.
科学领域:
- 兽医病毒学 兽医病毒学
- 分子流行病学分子流行病学
- 动物健康经济学 动物健康经济学
背景情况:
- 猪流行性腹病毒 (PEDV) 于2013年在美国出现,在猪群中造成了重大经济损失.
- 已经确定了两个主要菌株,S-INDEL和非S-INDEL,在美国流通.
研究的目的:
- 分析PEDV在美国自引入以来的基因组和Spike蛋白序列数据.
- 了解循环PEDV菌株的进化动态,流行率和地理分布.
- 根据当前的菌株特征和传播模式,评估PEDV重新引入的风险.
主要方法:
- 对313个PEDV基因组和556个Spike蛋白序列的分析.
- 遗传学分析以确定菌株关系和分类.
- 对序列数据进行时间和地理映射,以追踪PEDV的演变和传播.
主要成果:
- 非S-INDEL菌株是美国占主导地位的PEDV菌株,具有高核酸标识 (>97.6%).
- 2017年后非S-INDEL序列聚集成两个不同的子类,旧的类不再被检测到.
- 目前流通的克莱德表现出地理限制,这表明区域间传播有限.
结论:
- 非S-INDEL菌株主导美国PEDV,目前有两种主要菌株在流传,地理分布有限.
- 了解当前的菌株分布和有限的传播,帮助评估区域消除后的再引入风险.
- 持续的分子监测对于监测PEDV演变,确认类消失和绘制持续传播的地图至关重要.
相关概念视频
00:57Viral Recombination
23.8K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
23.8K
00:36Viral Mutations
33.2K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
33.2K
02:39Gene Flow
35.7K
Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.
35.7K