根据个体失塑性特征对口腔白血病的风险评估
Andresa Borges Soares1,2, Saman Warnakulasuriya3,4, Letícia da Silveira Terra Junqueira1
1Faculdade São Leopoldo Mandic, Campinas, São Paulo, Brazil.
概括
口腔白血病 (OL) 恶性转变 (MT) 风险是由特定的口腔上皮质失调 (OED) 特征预测的. 凝聚力丧失,核细胞增加和炎症是关键指标,它们的总和是最有用的预测指标.
科学领域:
- 口腔病理学 口腔病理学
- 在瘤学瘤学.
- 生物统计学 生物统计学
背景情况:
- 口腔白血病 (OL) 是一种癌前病变,需要对恶性转变 (MT) 的风险评估.
- 口腔上皮质异位症 (OED) 的分级是标准的,但对MT的个体OED特征的预测价值尚未完全理解.
研究的目的:
- 评估每个OED特征在预测OL患者MT中的作用.
- 确定在风险分层中最有效的特定OED特征及其组合.
主要方法:
- 分析了99名OL患者 (81名非转化,18名有MT) 的个人OED特征评分.
- 使用了斯皮尔曼相关性,后勤回归和卡普兰-梅尔生存分析.
- 采用随机森林模型来确定特征相关性,并计算风险值的预测值.
主要成果:
- 表皮凝聚力的丧失,核细胞 (大小和数量) 的增加,以及炎症与MT显著相关 (p ≤0.016).
- 这三种特征的组合显示出高特异性 (95%) 和预测值 (50%正值,85%负值).
- 六个OED特征的门显示了对MT风险的适度预测能力.
结论:
- 表皮凝聚力的丧失,核细胞增加和炎症是预测OL中MT的OED关键特征.
- 在口腔白血病中,OED特征的总和是评估MT风险的最有价值的预测指标.
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