双S暴露对实验性喘发展的跨代影响
Terumi Midoro-Horiuti1, Yoko Murakami1, Kazuyo Kuzume1
1Department of Pediatrics, University of Texas Medical Branch, Galveston, TX, USA.
在怀孕的小鼠中,双S (BPS) 暴露导致后代多代喘的发展. 这表明BPS可能会跨世代对儿童喘构成风险.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 免疫学 免疫学 免疫学
背景情况:
- 早期接触双甲 (BPA) 与增加儿童喘有关.
- 双S (BPS) 是一种常见的BPA替代品,引发了人们对其安全性的担忧.
- 了解BPS对喘发展的影响对于公共卫生至关重要.
研究的目的:
- 调查早期双S (BPS) 暴露对儿童喘发展的影响.
- 评估BPS暴露对小鼠喘表型的多代影响.
主要方法:
- 雌性BALB/c小鼠 (F0) 从怀孕前到F1断奶时,在饮用水中接受了10μg/ml的BPS.
- 后代 (F1-F4) 用卵蛋白 (OVA) 敏感化,并评估喘标志物.
- 测量了过敏原特定的IgE,IgG1,呼吸道炎症和高反应性.
主要成果:
- 暴露于BPS的小狗在敏感化后表现出喘现型.
- 在F1-F4世代的BPS暴露母亲中观察到增强的喘表型.
- 母亲BPS暴露对实验性喘发育产生了多代影响.
结论:
- 母亲接触双S (BPS) 可以诱导多代喘的发展.
- 跨世代的BPS可能会对儿童喘构成重大风险.
- 需要进一步的研究来评估BPS的安全性及其对健康的长期影响.
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