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多基因相互作用与抗胆固醇负担对精神病谱系障碍的认知和大脑结构的影响
Lusi Zhang1, Elena I Ivleva1, David A Parker1
1Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis (Zhang, Bishop); Department of Psychiatry, Southwestern Medical Center, University of Texas, Dallas (Ivleva, Tamminga); Department of Psychology and Neuroscience, University of Georgia, Athens (Parker, McDowell, Clementz); Department of Human Genetics, Emory University School of Medicine, Atlanta (Parker); Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago (Hill); Department of Psychiatry (Lizano, Keshavan) and Division of Translational Neuroscience (Lizano), Beth Israel Deaconess Medical Center, Boston; Department of Psychiatry, Harvard Medical School, Boston (Lizano, Keshavan); Departments of Psychiatry, Neuroscience, and Psychology, Duke University, Durham, NC (Keefe); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (Keedy, Gershon); Departments of Psychiatry and Neurobiology, School of Medicine, Yale University, New Haven, CT (Pearlson); Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati (Sweeney); Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis (Bishop).
遗传倾向与抗胆固醇负担 (AChB) 相互作用,影响精神障碍患者的认知和大脑结构. 这种基因与环境的相互作用为认知障碍提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
背景情况:
- 抗胆固醇负担 (AChB) 在精神疾病中很常见,并与认知缺陷有关.
- 遗传因素可能会影响个体对 AChB 影响的敏感性.
研究的目的:
- 调查遗传倾向 (认知能力,精神疾病) 与 AChB 在精神疾病中的认知和大脑结构之间的相互作用.
主要方法:
- 1,704名患有精神病谱系障碍的参与者接受了认知测试,神经成像和基因定型.
- 药物审查量化了AChB;计算了认知和精神疾病的多基因分数 (PGS).
- 线性回归和调节调解模型分析了 AChB-PGS 相互作用.
主要成果:
- 较高的ACHB与较差的认知表现 (BACS) 和减少的灰质体积相关.
- 高认知PGS放大了AChB的负面认知影响;低精神病PGS放大了AChB的灰质减少.
- AChB的认知效应部分由灰质体积调节,部分由精神病学PGS调节.
结论:
- 抗胆固醇暴露与遗传因素之间的基因与环境相互作用在精神疾病中显著影响认知和大脑结构.
- 这一发现推动了对这一群体认知障碍的机制学理解.
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