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纳米和微塑料:揭示它们对内分泌健康的深刻影响

Faezeh Jahedi^1,2, Neamatollah Jaafarzadeh Haghighi Frad^2,3, Mohammad Ali Khaksar¹

¹Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Toxicology mechanisms and methods

|May 28, 2025

概括

微型和纳米塑料 (MNP) 破坏内分泌功能,影响生殖激素并增加炎症. 接触这些塑料颗粒对人类健康构成重大风险,需要采取紧急的减轻策略.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
内分泌学在内分泌学.

背景情况:

塑料污染是全球日益关注的问题,原因是塑料的环境持久性和广泛使用.
微型和纳米塑料 (MNP) 在人体组织中越来越多地被检测到,这引发了关于它们对健康的影响的问题.
内分泌系统特别容易受到环境污染物的干扰.

研究的目的:

系统地审查MNP对内分泌系统的影响.
从体外和体内生物实验模型中综合发现.
识别知识缺口,并建议未来的研究方向.

主要方法:

按照PRISMA指南进行系统的文献搜索.
搜索的数据库:PubMed,科学网络,Scopus.
纳入标准:关于MNP对内分泌的影响的研究,体外和体内模型,英语.

主要成果:

许多MNP会破坏内分泌功能,改变生殖荷尔蒙和基因表达.
在体内暴露会提高炎症标志物 (TNF-α,IL-6,IL-1β,NF-κB),诱导细胞亡,炎症和氧化应激.
观察到对生殖腺,甲状腺,垂体和下丘脑激素分泌的影响;聚乙烯是研究最多的聚合物.

结论:

许多MNP对内分泌系统功能和人类整体健康构成重大风险.
需要对各种塑料聚合物,更长时间暴露,不同度和人体研究进行进一步的研究.
减少MNP暴露需要改变政策,改变消费者行为和提高公众意识.

关键词:

微塑料是一种微塑料.内分泌的影响内分泌影响激素激素激素激素激素纳米颗粒是一种纳米粒子.生殖生殖的繁殖.甲状腺是什么?甲状腺是什么?

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