刺激剂相关心血管疾病死亡率和生命损失年数,2014年至2023年
Rebecca Arden Harris1,2,3, Sameed Ahmed M Khatana2,4,5, Dana A Glei6
1Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Substance use : research and treatment
|May 28, 2025
概括
从2014年到2023年,与兴奋剂有关的心血管疾病 (CVD) 死亡率急剧增加,特别是甲基胺和脑血管疾病. 这一趋势凸显了针对性预防和干预策略的迫切需要.
科学领域:
- 心血管医学 心血管医学
- 公共卫生 公共卫生
- 毒理学 毒理学 毒理学
背景情况:
- 可卡因和甲基胺是强大的心脏毒性兴奋剂.
- 这些药物增加了高血压,冠状动脉疾病,心律失常,心肌病和中风的风险.
研究的目的:
- 分析2014年至2023年美国兴奋剂相关心血管疾病 (CVD) 死亡率的趋势.
- 检查心血管疾病的亚型,兴奋剂类型,人口特征和丧失的生命年数 (YLL).
主要方法:
- 使用国家生命统计系统数据 (2014-2023年).
- 分析了对心血管疾病的年龄调整死亡率 (AAMR) 作为潜在原因与兴奋剂贡献.
- 用于趋势分析的就业joinpoint回归 (AAPC) 和计算的YLL.
主要成果:
- 与兴奋剂有关的心血管疾病死亡率每年升10.1%,与稳定的整体心血管疾病死亡率 (0.2%) 相比.
- 涉及甲基胺的死亡人数比涉及可卡因的死亡人数 (6.5%) 增加得更快 (13.8%).
- 脑血管疾病增长最快 (15.9%),紧随其后的是高血压 (12.1%) 和缺血性心脏病 (7.9%).
- 老年人 (≥65岁) 的增幅最高 (20.2%);非西班牙裔美国印第安人/阿拉斯加土著人口的AAPC最高 (18.1%).
- 将近100万年的生命损失 (YLL) 归因于涉及兴奋剂的心血管疾病,主要是中年男性和非西班牙裔白人.
结论:
- 刺激剂涉及心血管疾病的死亡率显著增加,特别是影响老年人和特定的种族/民族群体.
- 脑血管疾病在心血管疾病亚型中表现出最显著的增长.
- 研究结果强调了针对性预防,查和干预策略的必要性,以减轻这种日益严重的公共卫生危机.
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