选择基于实验室的生物标志物,用于评估风险人群中维生素A缺乏症
Bryan M Gannon1,2, Samantha L Huey1,3, Neel H Mehta1
1Division of Nutritional Sciences, Cornell University, Ithaca, New York, USA.
The Cochrane database of systematic reviews
|May 28, 2025
概括
准确诊断维生素A缺乏症至关重要. 目前的诊断测试显示敏感度低 (0-54%),但特异性高 (74-94%),尽管由于研究的局限性,必须谨慎解释结果.
科学领域:
- 生物化学 生物化学
- 营养科学 营养科学
- 诊断准确性研究 诊断准确性研究
背景情况:
- 维生素A 缺乏带来了重大的全球健康风险,包括生长障碍,免疫力减弱,增加疾病易感性和死亡率.
- 可靠的诊断方法对于有效的临床治疗维生素A缺乏是必不可少的.
- 现有的诊断工具包括直接指数测量和剂量反应生物标志物.
研究的目的:
- 评估常用的亚临床维生素A缺乏指数测试的诊断准确性.
- 根据共变量来确定测试准确性的异质性潜在来源.
主要方法:
- 诊断准确性研究的系统审查和元分析.
- 在多个数据库 (CENTRAL,MEDLINE,Embase等) 进行了搜索. 在2022年8月之前.
- 包括使用参考标准和索引测试测量维生素A状态的研究;使用QUADAS-2评估偏差风险.
主要成果:
- 包括40项研究 (65项记录);没有一个被设计为诊断测试准确性研究.
- 与参考标准相比,血清/血视网醇 (SR) 的综合敏感性低 (10-54%),特异性中等至高 (79-94%).
- 视网醇结合蛋白 (RBP) 显示了低至中等的综合敏感性 (0-50%) 和高特异性 (76-98%). 相对剂量响应 (RDR) 显示了有限的可估计灵敏度,但具有高的特异性 (89-91%).
结论:
- 目前用于诊断维生素A缺乏症的方法通常具有低灵敏度和高特异性.
- 由于包含的研究的诊断测试准确性设计有限,研究结果应谨慎解释.
- 需要对母乳维生素A和修改RDR测试的准确性进行更多研究.
更多相关视频
08:18Author Spotlight: Unraveling Vitamin A Transport Mechanisms — Linking Liver Receptors to Vision Health Through RBPR2 and RBP4 Interactions
Published on: October 4, 2024
1.2K
07:20Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
Published on: January 28, 2014
36.7K
相关概念视频
01:23Role of Skin in Vitamin D Synthesis
5.8K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.8K
01:30Vitamins
1.0K
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
1.0K