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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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缓解细胞循环效应在多态数据中的数据:解决方案和分析框架.

Rui Nie1,2, Caihong Zheng3, Likun Ren1,2

  • 1Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
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概括
此摘要是机器生成的。

细胞周期变化会在多组数据中产生噪音,影响复制数变化和染色质可访问性. 特定阶段分析或复制时限域的校正可以改善omics数据的解释.

关键词:
在 S 阶段比率上.细胞周期的组成 细胞周期的组成伪经济学的特点是伪经济学的特点.

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科学领域:

  • 基因组学就是基因组学.
  • 细胞生物学 细胞生物学
  • 生物信息学是一种生物信息学.

背景情况:

  • 细胞周期异质性显著影响多组数据的解释,原因是DNA剂量,染色质可访问性,甲基化和基因表达的变化.
  • 细胞周期阶段组成对奥米克数据分析的确切影响仍然在很大程度上未被描述.

研究的目的:

  • 系统地评估不同的细胞周期阶段结构如何影响在增殖细胞中的各种奥米克特征的解释.
  • 提出数据处理解决方案,以减轻与细胞循环相关的遗传物在omics数据集中的影响.

主要方法:

  • 评估了细胞相结构对拷贝数变异 (CNV) 调用,染色质可访问性,DNA甲基化和转录组数据的影响.
  • 应用复制时间域 (RTD) 校正以减轻 CNV 调用错误.
  • 利用细胞循环分类进行DNA甲基化和转录组分析.
  • 开发了一种集成的管道,用于在细胞周期分相后识别差异表达基因 (DEG).

主要成果:

  • 异步复制时间 (RT) 在具有高S相比 (SPR) 的细胞中引起虚假的CNV,该SPR通过RTD校正来减少.
  • 在染色质可访问性数据中也观察到类似的噪声人工物.
  • 与直接比较相比,细胞周期排序的数据为DNA甲基化和转录基因分析提供了卓越的生物学见解.
  • 一个集成的管道有效地识别了DEGs的细胞循环后阶段化.

结论:

  • 广泛的细胞循环异质性需要在多组学研究中考虑,特别是在具有多种细胞循环组成的细胞中.
  • 复制时间域修正或特定阶段比较是有效的策略,可以减少细胞周期对奥米克数据分析的影响,特别是在比较干细胞和分化细胞时.