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功能性消化不良及其子组:在罗马IV全球流行病学研究中的流行率和影响
J Tack1,2,3,4, O S Palsson1, S I Bangdiwala1,5,6
1Rome Foundation Research Institute, Raleigh, North Carolina, USA.
Alimentary pharmacology & therapeutics
|May 28, 2025
概括
功能性消化不良 (FD) 是一种常见的肠-大脑相互作用障碍,在全球范围内影响7.2%,特别是女性. 它显著影响生活质量和医疗保健使用,食后应急综合征是主要的亚型.
科学领域:
- 胃肠病学 胃肠病学
- 心理学 心理学 心理学
- 流行病学 流行病学
背景情况:
- 功能性消化不良 (FD) 是一种高度流行的肠脑相互作用 (DGBI) 障碍.
- 以前的FD流行率估计因不同定义和方法而有所不同.
- 了解FD的全球流行和影响对于公共卫生至关重要.
研究的目的:
- 使用"罗马四号标准"确定功能性消化不良 (FD) 的全球患病率和影响.
- 为了确定最常见的FD子组.
- 评估FD与心理痛苦和生活质量的关联.
主要方法:
- 在26个国家对54,127名参与者进行了基于互联网的调查.
- 该调查包括罗马IV诊断问卷,PHQ-4,PHQ-12,PROMIS Global-10以及人口统计/病史.
- 排除标准包括有机疾病,自我诱导吐,周期性吐或大麻素过度复杂.
主要成果:
- 罗马四号FD的全球患病率为7.2%,不同国家有显著差异 (2.2%-12.3%).
- 餐后应急综合征 (PDS) 是最常见的亚型,占FD病例的66.6%.
- FD症状标准与更高的焦虑,抑郁,生活质量下降和医疗保健利用率增加有关.
结论:
- 罗马四号FD是全球普遍存在的DGBI,不成比例地影响女性和年轻人.
- 飞行障碍与心理困扰,生活质量下降和医疗保健需求增加有关.
- 餐后应急综合征是占主导地位的FD亚型,少数人经历重叠的DGBI.
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