肠道微生物组干预:从失生症到下一代益生菌 (NGP) 用于疾病管理
Mandeep Kumar Gupta1, Rajnish Srivastava2
1Moradabad Educational Trust Group of Institutions Faculty of Pharmacy, Moradabad, 244001, Uttar Pradesh, India. mandeepkrgupta@gmail.com.
Probiotics and antimicrobial proteins
|May 28, 2025
概括
肠道微生物群影响健康,其不平衡 (失衡) 与许多慢性疾病有关. 本综述探讨了下一代益生菌 (NGP) 和心理生物的潜在治疗应用.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物群,一个复杂的微生物生态系统,在宿主健康中起着至关重要的作用.
- 肠道微生物群不平衡的失生症与许多慢性炎症疾病有关,包括代谢综合征,糖尿病,心血管疾病,癌症和神经退行性疾病.
- 最近的技术进步加速了微生物组研究.
研究的目的:
- 审查潜在的下一代益生菌 (NGP) 和它们的治疗应用.
- 探索精神生物药在神经发育和神经退行性疾病中的作用.
- 讨论NGP发展当前的趋势,局限性和未来的研究方向.
主要方法:
- 关于微生物组研究近期进展的文献综述.
- 对特定下一代益生菌 (NGP) 的研究分析,如Faecalibacterium prausnitzii,Akkermansia muciniphila等.
- 对神经疾病的精神生物应用的检查.
主要成果:
- 几种特定的细菌菌株 (例如,Faecalibacterium prausnitzii,Akkermansia muciniphila) 显示出作为NGP的希望.
- 精神生物药物,包括某些乳酸菌和双菌,显示出治疗神经发育和神经退行性疾病的潜力.
- 微生物组治疗领域正随着新技术的发展而迅速发展.
结论:
- NGP和精神生物药物代表了新型治疗策略的前沿.
- 需要进一步的协作转化研究,才能充分发挥基于微生物组的干预措施的潜力.
- 解决NGP研究当前的局限性对于开发未来有效的治疗方法至关重要.
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