在患者报告的肝病结局测量得分中的有意义的差异
Archita P Desai1, Eric S Orman1, Tarek G Aridi2
1Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Hepatology communications
|May 28, 2025
概括
本研究确定了慢性肝病 (CLD) 中患者报告的结果措施 (PROM) 的最小有意义差异 (MSD). 这些发现改善了PROM数据在CLD研究和临床护理中的解释.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 临床研究 临床研究
- 患者报告的结果
背景情况:
- 患者报告结果测量 (PROM) 越来越多地用于慢性肝病 (CLD) 护理和研究.
- 确定最小的有意义分数差 (MSD) 对于解释CLD中的PROM数据至关重要.
- 这项研究报告了肝病各个阶段PROM的得分和MSD.
研究的目的:
- 确定慢性肝病 (CLD) 患者常用PROM的最小有意义分数差异 (MSD).
- 提高PROM数据在临床治疗和研究中的可解释性.
- 在肝病的不同阶段为PROM解释提供基于数据的建议.
主要方法:
- 来自2442名患有CLD的成年人的综合得分,分为四个阶段:去补偿性肝硬化,肝硬化,CLD和肝移植接受者.
- 利用患者报告结果测量信息系统 (PROMIS) -29 个人资料,慢性肝病问卷 (CLDQ) 和简短表格-36 (SF-36) v1.0.0.
- 使用基于分布和基于的方法估计的MSD.
主要成果:
- 住院患者中PROMIS域中位数最低,移植后最高.
- 对于PROMIS,MSDs在个别领域的范围为3-4个,总结得分为4-6个.
- 对于CLDQ的MSD是1,对于SF-36的个别领域是7-18,组件分数为3. 在疾病各个阶段,PROMIS MSDs 呈现相似,在无补偿患者中略小一些.
结论:
- 为肝病中常见的PROMs的MSD提供了基于数据的建议.
- 提高了在CLD中的PROM分数的可解释性.
- 促进PROMs在临床实践和肝病管理研究环境中的整合.
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