内皮功能障碍与慢性大麻吸烟和THC可食用使用的关联
Leila Mohammadi1, Mina Navabzadeh1, Nerea Jiménez-Téllez2
1Division of Cardiology, University of California, San Francisco.
JAMA cardiology
|May 28, 2025
概括
慢性大麻吸烟和THC摄入与内皮功能障碍有关,影响血管健康类似于烟草. 需要进一步的研究,以了解涉及大麻相关血管效应的独特机制.
科学领域:
- 心血管研究研究心血管研究
- 内皮功能研究 研究内皮功能研究.
- 大麻与健康 大麻与健康
背景情况:
- 娱乐和医用大麻的合法化增加了使用.
- 了解大麻对血管健康的影响至关重要.
研究的目的:
- 调查大麻使用与血管内皮功能障碍之间的关联.
- "大麻:是否会损害内皮 (CANDIDE) "研究是为了探索这些影响而启动的.
主要方法:
- 一项涉及18-50岁健康成年人的横截面研究,分为大麻吸烟者,THC可食用用户和非用户.
- 测量包括动脉流介导扩张 (FMD) 和脉冲波速度 (PWV).
- 使用暴露于参与者血清的人类静脉内皮细胞 (HUVEC) 评估了内皮氧化的产量.
主要成果:
- 与非使用者相比,大麻吸烟者和THC可食用的使用者表现出明显较低的口炎.
- 在大麻吸烟者中,VEGF刺激的氧化水平较低,但在可食用THC的使用者中并非如此.
- 关节炎与吸烟频率和THC摄入量有反向相关性.
结论:
- 慢性大麻吸烟和THC摄入与内皮功能障碍有关.
- 观察到的内皮功能障碍类似于烟草吸烟者的内皮功能障碍,但可能涉及不同的机制.
- 大麻使用对血管健康构成风险,因此需要对其特定途径进行进一步调查.
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