在博物馆中暴露于真菌,细菌和内毒素,工作人员报告了与工作有关的症状
Anne Mette Madsen1, Margit W Frederiksen1, Hjördís Birna Árnadóttir1
1National Research Centre for the Working Environment, Copenhagen Ø, Denmark.
Journal of occupational and environmental hygiene
|May 28, 2025
概括
博物馆工作人员因空气中的真菌,细菌和内毒素暴露而出现了呼吸道症状. 在文物上发现了高水平的真菌,主要是Aspergillus和Cladosporium,与症状有关,需要采取预防策略.
科学领域:
- 环境微生物学环境微生物学
- 职业健康 职业健康 职业健康 职业健康
- 室内空气质量 室内空气质量
背景情况:
- 在室内环境中对空气中的真菌的职业暴露会带来呼吸风险.
- 博物馆工作人员报告了呼吸道症状,促使对室内空气质量进行调查.
研究的目的:
- 在历史博物馆中对真菌,细菌和内毒素的暴露的特征.
- 为了将空气中的污染物与工作人员报告的呼吸道症状相关联.
- 评估室内空气样本的炎症潜力.
主要方法:
- 使用个人和固定采样器在三个工作日内采样空气样本.
- 使用MALDI-TOF进行真菌和细菌的量化和鉴定MS.
- 在人类细胞系中测量反应性氧物种 (ROS) 生产,以评估炎症潜力.
主要成果:
- 工作人员的暴露水平:5.9×103 CFU/m3真菌,1.8×103 CFU/m3细菌,7.93 EU/m3内毒素.
- 增加的真菌度 (主要是Aspergillus spp. 和Cladosporium spp.) 的类型. 在部门报告人员呼吸道症状的部门.
- 在博物馆文物上检测到的真菌,在处理文物时真菌和细菌度增加.
- 诱导的ROS产生与真菌,细菌和内毒素度相关.
结论:
- 症状部门的员工暴露于高水平的真菌 (2×104到7×104 CFU/m3),包括异性恋和水损坏的建筑物物种,可能来自文物.
- 研究结果强调了需要采取预防策略来保护博物馆工作人员的健康.
- 强调了对艺术品适应不同湿度条件的真菌管理的挑战.
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