控制营养状况预测了切除非小细胞肺癌与间歇性肺病的术后生存率和急性恶化
Taichi Matsubara1, Mototsugu Shimokawa2, Sho Wakasu1
1Department of Thoracic Surgery, Kitakyushu Municipal Medical Center, 2-1-1 Bashaku, Kokurakita-Ku, Kitakyushu, Japan.
控制营养状况 (CONUT) 评分是切除肺癌和间歇性肺病 (ILD) 患者的显著预后因素. 较高的CONUT分数表明这些患者的术后急性恶化 (AE) 风险增加.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 营养科学 营养科学
背景情况:
- 免疫营养标志物是肺癌等恶性瘤的已知的预后因素.
- 控制营养状况 (CONUT) 评分显示了切除肺癌的预后价值.
- 在切除的肺癌与间歇性肺病 (ILD) 中,CONUT评分的作用仍未得到研究.
研究的目的:
- 为了评估CONUT得分在切除非小细胞肺癌 (NSCLC) 复杂的ILD.患者的意义.
- 确定CONUT得分是否是该患者队列中术后急性恶化 (AE) 的独立风险因素.
主要方法:
- 分析了一组120名患有NSCLC和ILD的患者进行肺切除.
- 根据CONUT得分,患者被分为三组:正常 (0-1),轻度营养不良 (2-4),中度营养不良 (5-8).
- 使用后勤回归分析来确定AE的风险因素.
主要成果:
- 手术后AE发生在13.7%的患者中,营养不良群体的发病率更高 (9%正常,16%轻度,33%中度).
- CONUT评分被确定为AE的独立风险因素.
- 其他独立的风险因素包括性别,手术技术,ILD成像,先前的AE史,类固醇使用,KL-6水平和预测的生命能力.
结论:
- 在切除肺癌和ILD患者中,CONUT得分是显著的预后因素.
- 该CONUT得分独立预测了该人群中术后急性恶化的风险.
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