承认中性粒细胞/淋巴细胞比率和第一次急性缺血性中风的严重程度在西非土著人中
Oladotun V Olalusi1, Joseph Yaria2, Adekunle Fakunle3
1Department of Neurology, University College Hospital, Ibadan, Nigeria; Neuroscience and aging research unit, Institute of Advanced Medical Research and Training, College of Medicine, University of Ibadan, Nigeria.
Journal of the neurological sciences
|May 28, 2025
概括
中性粒细胞 - 淋巴细胞比率 (NLR) 可以识别低资源环境中的严重中风患者. 这种简单的血液检测,即NLR,在资源有限的情况下,可能是复杂的评分系统的可行替代方案.
科学领域:
- 神经学 神经学
- 血液学 血液学 血液学
- 生物标志物 生物标志物
背景情况:
- 中性粒细胞-淋巴细胞比率 (NLR) 是一种潜在的炎症生物标志物.
- 在资源较少的环境中评估中风严重程度存在挑战,原因是国家卫生研究院中风量表 (NIHSS) 等复杂量表的培训人员有限.
研究的目的:
- 评估中性粒细胞-淋巴细胞比率 (NLR) 单独是否可以在资源有限的环境中识别严重急性缺血性中风 (AIS).
- 为了比较单独的NLR与NLR和NIHSS结合的分辨能力,以识别严重的中风.
主要方法:
- 一项研究包括212名参与者:106名有AIS和106名对照.
- 使用中风轻度度量 (SLS) 和NIHSS评估中风严重程度. 在入院时测量了NLR.
- 多变量线性回归确定了严重中风的预测因子 (SLS ≤ 5),并将ROC曲线与NLR与NLR+NIHSS进行了比较,以获得诊断准确度.
主要成果:
- 与对照组相比,患有AIS的患者的中位数NLR显著更高 (2.87比0.98,p<0.001).
- 基线NLR是严重缺血性中风 (SLS ≤5) 的独立预测因素.
- 单独NLR显示出良好的区分能力 (AUC 0.82),与NLR+NIHSS (AUC 0.85) 相比.
结论:
- 升高的入院NLR与严重的AIS独立相关.
- 在资源有限,NIHSS培训人员有限的环境中,单独的NLR可以作为识别严重AIS患者的实用工具.
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